Polysulfone is modified via chloromethylation and TiO₂ is functionalized by three modification reagents (anionic surfactant, 1,3-propane sultone and Dopamine). Based them, a series of promising organic-inorganic hybrid membranesn for anion-exchange membrane fuel cells have been prepared by incorporating functionalized TiO₂ submicrospheres into the chloromethylated polysulfone, subsequent quaternization and alkalization. The chloromethylation process is confirmed by Nuclear magnetic resonancespectra. The functionalization of TiO₂ is proved through Fourier transform infrared spectroscopy and Thermogravimetric analysis. The quaternization is testified by contact angle measurement. Associated characteristics of the hybrid membranes were investigated, including water upatke, swelling behavior, mechanical property and ion conductivity. Compared with other anion-exchange membranes, the hybrid membranes containing 5% TiO₂ with –SO₃H groups exhibits higher ionic conductivity because of the acid-base ionic interactions between the inorganic filler and polymer chains. It demonstrates an ionic conductivity of 3.13×10^-2 S/cm and an acceptable alkaline solution stability at 60 ^oC.